Why Depression Isn’t What We Think | Lisa Monteggia | TED

传统抗抑郁理论的局限

But here's the thing. If you look at individuals with depression, many of them don't have decreased serotonin. They have normal levels. And that's a surprise to many people. This idea that we had a measurable index of depression just because it was less serotonin, many people talked about, but it really wasn't true. So that's been sort of surprising to many people.

But importantly, SSRIs still are incredibly important treatment options. They help many people. They are life changing and they are life saving. For many people, they really give them the will to live. The thing about SSRIs is that when you take them, you have this increase in serotonin very quickly, but they take weeks to work. They don't work quickly.

氯胺酮的快速疗效与机制（一）

And for those individuals that were depressed that received ketamine, they had a rapid antidepressant effect -- not within weeks, within hours. We didn't even know it was possible to have an antidepressant effect that rapidly. And so people have been studying why. What is this rapid effect? Because it really is remarkable. And it doesn't just work in individuals that could be depressed. It's really been studied in individuals that don't respond to SSRIs, because not everyone responds.